Nestled in Santa Croce, which is a laid-back, slightly off-the-beaten-track area with a local vibe, Ca' Spezier Hotel Venice is within 5 minutes' walk of culture-oriented attractions like Jewish Museum of Venice.

The public Ca' Rezzonico Museum is just 1.7 km from this Venice guest house, while Basilica dei Santi Giovanni e Paolo is within close distance of the location. The property is at a distance of 900 metres from Venezia Piazzale Roma bus stop and only 5 minutes on foot from Ponte di Rialto. Nature lovers will appreciate the proximity to bacino Orseolo, which is about 15 minutes' walk away. Guests can visit historical sights, including Casino Vendramin-Calergi Palace, located within easy walking distance of the hotel, and learn more about Venice. For those travelling from afar, Marco Polo airport is 16 minutes' drive away.

Serving Mediterranean meals, Muro San Stae lies at a distance of 250 metres from the property.